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Damelang, Timon, Aitken, Elizabeth H., Hasang, Wina, Lopez, Ester, Killian, Martin, Unger, Holger, Salanti, Ali, Shub, Alexis, McCarthy, Elizabeth, Kedzierska, Katherine, Lappas, Martha, Kent, Stephen J., Rogerson, Stephen J. and Chung, Amy W. (2021) 'Antibody mediated activation of natural killer cells in malaria exposed pregnant women'. Scientific Reports, Vol 11, p. 4130.
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41598_2021_Article_83093.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Article, /631/250, /692/699, article |
| Subjects: | QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QX Parasitology > Protozoa > QX 135 Plasmodia WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WQ Obstetrics > Pregnancy > WQ 200 General works |
| Faculty: Department: | Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41598-021-83093-4 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 19 Feb 2021 09:25 |
| Last Modified: | 19 Feb 2021 09:25 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/17009 |
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