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Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Molloy, Síle F, Ross, Brad, Kanyama, Cecilia, Mfinanga, Sayoki, Lesikari, Sokoine, Heyderman, Robert, Kalata, Newton, Ellis, Jayne, Kouanfack, Charles, Chanda, Duncan, Temfack, Elvis, Lakhi, Shabir, Moodley, Anand, Chan, Adrienne K, van Oosterhout, Joep J, Mapoure, Yacouba, Mwaba, Peter, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Lortholary, Olivier, Jaffar, Shabbar ORCID: https://orcid.org/0000-0002-9615-1588, Hosseinipour, Mina C, Loyse, Angela, Harrison, Thomas S and Bicanic, Tihana (2021) 'Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis'. Open Forum Infectious Diseases, Vol 8, Issue 4, ofab066.

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Abstract

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

Item Type: Article
Subjects: QW Microbiology and Immunology > Fungi. Pathogenic Fungi. > QW 180 Pathogenic Fungi
WC Communicable Diseases > Mycoses > WC 475 Cryptococcosis. Sporotrichosis
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WL Nervous System > WL 200 Meninges. Blood-brain barrier
WL Nervous System > WL 300 General works (Include works on brain alone)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI): https://doi.org/10.1093/ofid/ofab066
Depositing User: Rachel Dominguez
Date Deposited: 23 Feb 2021 11:45
Last Modified: 07 May 2021 13:51
URI: https://archive.lstmed.ac.uk/id/eprint/17043

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