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Sternberg, Eleanore, Cook, Jackie, Alou, Ludovic P Ahoua, Assi, Serge Brice, Koffi, Alphonsine A, Doudou, Dimi T, Aoura, Carine J, Wolie, Rosine Z, Oumbouke, Welbeck, Worrall, Eve 
ORCID: https://orcid.org/0000-0001-9147-3388, Kleinschmidt, Immo, N'Guessan, Raphael and Thomas, Matthew B
(2021)
'Impact and cost-effectiveness of a lethal house lure against malaria transmission in central Côte d'Ivoire: a two-arm, cluster-randomised controlled trial'. Lancet, Vol 397, Issue 10276, pp. 805-815.
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18_Sternbert et al 2021 SET impact and costeffectiveness.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Background
New vector control tools are required to sustain the fight against malaria. Lethal house lures, which target mosquitoes as they attempt to enter houses to blood feed, are one approach. Here we evaluated lethal house lures consisting of In2Care (Wageningen, Netherlands) Eave Tubes, which provide point-source insecticide treatments against host-seeking mosquitoes, in combination with house screening, which aims to reduce mosquito entry.
Methods
We did a two-arm, cluster-randomised controlled trial with 40 village-level clusters in central Côte d'Ivoire between Sept 26, 2016, and April 10, 2019. All households received new insecticide-treated nets at universal coverage (one bednet per two people). Suitable households within the clusters assigned to the treatment group were offered screening plus Eave Tubes, with Eave Tubes treated using a 10% wettable powder formulation of the pyrethroid β-cyfluthrin. Because of the nature of the intervention, treatment could not be masked for households and field teams, but all analyses were blinded. The primary endpoint was clinical malaria incidence recorded by active case detection over 2 years in cohorts of children aged 6 months to 10 years. This trial is registered with ISRCTN, ISRCTN18145556.
Findings
3022 houses received screening plus Eave Tubes, with an average coverage of 70% across the intervention clusters. 1300 eligible children were recruited for active case detection in the control group and 1260 in the intervention group. During the 2-year follow-up period, malaria case incidence was 2·29 per child-year (95% CI 1·97–2·61) in the control group and 1·43 per child-year (1·21–1·65) in the intervention group (hazard ratio 0·62, 95% CI 0·51–0·76; p<0·0001). Cost-effectiveness simulations suggested that screening plus Eave Tubes has a 74·0% chance of representing a cost-effective intervention, compared with existing healthcare activities in Côte d'Ivoire, and is similarly cost-effective to other core vector control interventions across sub-Saharan Africa. No serious adverse events associated with the intervention were reported during follow-up.
Interpretation
Screening plus Eave Tubes can provide protection against malaria in addition to the effects of insecticide-treated nets, offering potential for a new, cost-effective strategy to supplement existing vector control tools. Additional trials are needed to confirm these initial results and further optimise Eave Tubes and the lethal house lure concept to facilitate adoption.
| Item Type: | Article |
|---|---|
| Subjects: | QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WA Public Health > Housing. Buildings. Public Facilities > WA 795 Housing WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/s0140-6736(21)00250-6 |
| Depositing User: | Samantha Sheldrake |
| Date Deposited: | 01 Mar 2021 09:55 |
| Last Modified: | 01 Mar 2021 09:55 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/17086 |
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