One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel

Boateng, Lilian, Schonewille, Henk, Ligthart, Peter C., Javadi, Ahmad, Veldhuisen, Barbera, Osei-Akoto, Alex, Dei-Adomakoh, Yvonne, Bates, Imelda ORCID: https://orcid.org/0000-0002-0862-8199 and Van der Schoot, C. Ellen (2021) 'One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel'. Haematologica, Vol 106, Issue 8, pp. 2274-2276.

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Abstract

Studies on red blood cell (RBC) antibodies in Africa routinely use standard test cells from donors of Caucasian descent. There are no systematic data on alloimmunization against antigens that are almost exclusively present in Africans. We studied the prevalence of antibodies in transfused Ghanaian patients with sickle cell disease (SCD) using standard test cells (representing predominantly antigens more common in Caucasians (Caucasian antigens) and cells expressing antigens more common among Africans (African antigens). Antibodies were present in 16% of 221 patients; 31% of these were directed against African antigens that were not detected with standard test cells. Our findings are not only relevant for an African setting, but also for Western blood banks that are developing strategies to recruit more African donors.

Item Type:	Article
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WH Hemic and Lymphatic Systems > WH 100 General works WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 170 Hemolytic anemia (e.g., Sickle cell anemia)
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.3324/haematol.2021.278451
Depositing User:	Stacy Murtagh
Date Deposited:	06 Apr 2021 12:23
Last Modified:	02 Aug 2021 11:28
URI:	https://archive.lstmed.ac.uk/id/eprint/17448

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