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Severe acute respiratory syndrome coronavirus 2 escape mutants and protective immunity from natural infections or immunizations

Di Caro, Antonino, Cunha, Flavia, Petrosillo, Nicola, Beeching, Nicholas ORCID:, Ergonul, Oner, Petersen, Eskild and Koopmans, Marion P.G. (2021) 'Severe acute respiratory syndrome coronavirus 2 escape mutants and protective immunity from natural infections or immunizations'. Clinical Microbiology and Infection, Vol 27, Issue 6, pp. 823-826.

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Although coronaviruses have lower mutation rates than other respiratory RNA viruses, the scale of the pandemic has brought the importance of viral evolution for coronaviruses to centre stage. It has long been known that coronaviruses can evolve through acquisition of mutations and through recombination, but knowledge in the field is far behind that of some other viruses with global reach. This pandemic has seen an unprecedented amount of genomic sequencing, which is starting to open up an entirely new field of research: real-time tracking of viruses on a global scale, and trying to predict what mutations and deletions may be relevant. During the global dissemination and long chains of transmission, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has diversified with accumulation of mutations. Many of these mutations are neutral, in the sense that they do not affect any of the properties of the virus, some reflect the geographical dispersal of the virus (founder effects), and some have raised concern because they may allow the virus to evade immunity generated in response to previous infection or enhance transmissibility through mechanisms that are as yet undefined [[1]]. Increasing population immunity through natural infections and immunizations will increase the selection pressure on the virus and probably increase the evolution of new escape mutants. This brief review examines virus variants and individual mutations of current concern, including evidence for their importance for transmission and pathogenicity.

Item Type: Article
Subjects: QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology
QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
Depositing User: Julie Franco
Date Deposited: 14 May 2021 13:35
Last Modified: 04 Jun 2021 10:14


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