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Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Mallia, Patrick, Meghji, Jamilah ORCID: https://orcid.org/0000-0002-4693-8884, Wong, Brandon, Kumar, Kartik, Pilkington, Victoria, Chhabra, Shaaan, Russell, Ben, Chen, Jian, Srikanthan, Karthikan, Park, Mirae, Owles, Harriet, Liew, Felicity, Alcada, Joana, Martin, Laura, Coleman, Meg, Elkin, Sarah, Ross, Clare, Agrawal, Shweta, Gardiner, Thomas, Bell, Aaron, White, Alice, Hampson, Dominic, Vithlani, Gauri, Manalan, Kavina, Bramer, Solange, Segura, Alejandra, Martin, Kucheria, Anushree, Ratnakumar, Prashanthi, Sheeka, Alexander, Anandan, Lavanya, Copley, Sue, Russell, Georgina, Bloom, Chloe I and Kon, Onn Min (2021) 'Symptomatic, biochemical and radiographic recovery in patients with COVID-19'. BMJ Open Respiratory Research, Vol 8, Issue 1, e000908.

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Abstract

Background
The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.
Methods
Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.
Results
75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR- positive and PCR- negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.
Conclusions
Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow- up of patients with COVID-19.

Item Type: Article
Subjects: QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology
WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1136/ bmjresp-2021-000908
Depositing User: Debbie Jenkins
Date Deposited: 27 May 2021 16:04
Last Modified: 27 May 2021 16:04
URI: https://archive.lstmed.ac.uk/id/eprint/17935

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