Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)

Donnellan, Samantha, Martínez-Rodríguez, Carmen, Aljayyoussi, Ghaith and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2021) 'Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)'. Methods in Molecular Biology, Vol 2296, pp. 393-408.

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Abstract

The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB, using high content imaging and pharmacokinetic/pharmacodynamic modeling.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Bacteria > QW 125 Actinibacteria, Actinomycetales. WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 360 Drug therapy WH Hemic and Lymphatic Systems > Lymphatic System > WH 650 Reticuloendothelial system
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1007/978-1-0716-1358-0_23
Depositing User:	Marie Hatton
Date Deposited:	08 Jul 2021 15:03
Last Modified:	21 Sep 2021 08:44
URI:	https://archive.lstmed.ac.uk/id/eprint/18151

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