Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis

Comella-Del-Barrio, Patricia, Molina-Moya, Bárbara, Gautier, Jacqueline, Villar-Hernández, Raquel, Doresca, Mariette Jean Coute, Sallés-Mingels, Beatriz, Canales-Aliaga, Lydia, Narcisse, Margareth, Pérez-Porcuna, Tomás M, Creswell, Jacob, Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 and Domínguez, José (2021) 'Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis'. Journal of clinical medicine, Vol 10, Issue 9, p. 1914.

	Text jcm-1176692_R1 - L Cuevas.docx - Accepted Version Restricted to Repository staff only Download (56kB)
Preview	Text jcm-10-01914 Luis Cuevas.pdf - Published Version Available under License Creative Commons Attribution. Download (274kB) | Preview

Abstract

Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. Fujifilm SILVAMP TB lipoarabinomannan (FujiLAM), a lateral-flow test to detect lipoarabinomannan in urine, is a novel non-sputum-based point-of-care diagnostic reported to have increased sensitivity for the diagnosis of TB among human immunodeficiency virus (HIV)-infected adults. We evaluate the performance of FujiLAM in children with presumptive TB. Fifty-nine children attending a paediatric hospital in Haiti with compatible signs and symptoms of TB were examined using Xpert MTB/RIF, smear microscopy and X-rays, and classified according to the certainty of diagnosis into bacteriologically confirmed TB ( = 5), unconfirmed TB (bacteriologically negative, = 50) and unlikely TB ( = 4). Healthy children ( = 20) were enrolled as controls. FujiLAM sensitivity and specificity were 60% and 95% among children with confirmed TB. FujiLAM's high specificity and its characteristics as a point-of-care indicate the test has a good potential for the diagnosis of TB in children.

Item Type:	Article
Subjects:	WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.3390/jcm10091914
Depositing User:	Julie Franco
Date Deposited:	08 Jul 2021 10:31
Last Modified:	08 Jul 2021 10:31
URI:	https://archive.lstmed.ac.uk/id/eprint/18282

Statistics

View details

Actions (login required)

Edit Item