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Sundar, S., Agrawal, S., Pai, K., Chance, Michael and Hommel, Marcel (2005) 'Detection of leishmanial antigen in the urine of patients with visceral leishmaniasis by a latex agglutination test'. American Journal of Tropical Medicine and Hygiene, Vol 73, Issue 2, pp. 269-271.
Full text not available from this repository.Abstract
Diagnosis of visceral leishmaniasis (VL) is usually done by demonstration of parasites in tissue smears. However, obtaining these smears may be risky, painful, and difficult. Antibody-based diagnostics are limited by their inability to predict active disease. In this study, a new latex agglutination test (KAtex), which detects parasite antigen in freshly voided and boiled urine, was evaluated in patients with VL before the start (n = 382) and at the end of treatment (n = 273); 185 healthy controls from leishmaniasis-endemic region were also studied. The KAtex result was positive in 87% (95% confidence interval [CI] = 83.3-90.3). However, at the end of treatment only 3% (95% Cl = 1.6-6.2) patients were positive. The specificity of the test was 99% and 2 of 185 healthy controls tested positive. Positive and negative predictive values were 0.994 and 0.788, respectively. KAtex is a promising test, and in a simplified and improved format it could be applied meaningfully in the diagnosis of VL.
| Item Type: | Article |
|---|---|
| Additional Information: | No DOI |
| Uncontrolled Keywords: | diagnosis coinfection samples |
| Subjects: | QY Clinical Pathology > Diagnostic Tests > QY 185 Urinalysis WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis |
| Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
| Related URLs: | |
| Depositing User: | Ms Julia Martin |
| Date Deposited: | 22 Sep 2011 10:02 |
| Last Modified: | 17 Aug 2022 08:56 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1845 |
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