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The surface of the Plasmodium falciparum-infected erythrocyte.

Smith, J. D. and Craig, Alister ORCID: (2005) 'The surface of the Plasmodium falciparum-infected erythrocyte.'. Current Issues in Molecular Biology, Vol 7, pp. 81-93.

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In order to navigate its complex lifecycle, the malaria parasites must interact with a range of host cells. Examples of this are the invasion of hepatocytes by sporozoites and erythrocyte invasion by merozoites. This requirement for cell recognition brings with it the need to display cognate ligands on the parasite surface, and therefore the capacity of the host to develop defences against the infection. Even at a stage where the intracellular nature of erythrocyte development would appear to offer an opportunity for the parasite to be immunologically " silent", parasite- derived proteins are found on the surface of the infected erythrocyte. This review will discuss the proteins found on or associated with the surface of the infected erythrocyte and the resulting phenotypes.

Item Type: Article
Uncontrolled Keywords: intercellular-adhesion molecule-1 human cerebral malaria red-blood-cells chondroitin sulfate proteoglycans microvascular endothelial-cells naturally acquired-immunity membrane protein-1 pfemp1 antigenic variation variant antigens human placenta
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 150 Erythrocytes
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Depositing User: Ms Julia Martin
Date Deposited: 15 Jul 2011 14:24
Last Modified: 11 Jan 2021 14:16


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