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Kamchedzer, Wala, Maheswara, Hendramoorthy, Squire, Bertie 
ORCID: https://orcid.org/0000-0001-7173-9038, Joekes, Elizabeth, Pai, Madhukar, Nliwasa, Marriott, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Webb, Emily, Corbett, Elizabeth L and MacPherson, Peter ORCID: https://orcid.org/0000-0002-0329-9613
(2021)
'Economic costs of accessing tuberculosis (TB) diagnostic services in Malawi: an analysis of patient costs from a randomised controlled trial of computer-aided chest x-ray interpretation'. Wellcome Open Research, Vol 6, p. 153.
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Economic costs of assessing TB iagnostic services in Malawi.pdf - Published Version Available under License Creative Commons Attribution. Download (568kB) | Preview |
Abstract
Background: Patients with tuberculosis (TB) symptoms in low-resource settings face convoluted diagnostic and treatment linkage pathways, incurring substantial health-seeking costs. In the context of a randomised trial looking at the impact of novel diagnostics such as computer-aided chest x-ray diagnosis (CAD4TB), we aimed to investigate the costs incurred by patients seeking TB diagnosis and whether optimised diagnostic interventions could result in a reduction in the cost faced by households. Methods: PROSPECT was a three-arm randomised trial conducted in a public primary health clinic in Blantyre, Malawi during 2018-2019 (trial arms: standard of care [SOC]; HIV testing [HIV]; HIV testing and CAD4TB [HIV/TB]). The direct and indirect costs incurred by 219 PROSPECT participants over the 56-day follow-up period were collected. Costs were deemed catastrophic if they exceeded 20% of annual household income. We compared mean costs and used generalised linear regression models to examine whether the interventions could result in a reduction in total costs. Results: The mean total cost incurred by all 219 participants was US$12.11 (standard error (SE): 1.86). The indirect and direct cost was US$8.47 (SE: 1.66) and US$3.64 (SE: 0.38), respectively. The mean total cost composed of 5.6% of the average annual household income. In total, 5% (9/180) of the participants with complete income data
Open Peer Review
Reviewer Status AWAITING PEER REVIEW Any reports and responses or comments on the article can be found at the end of the article.
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Wellcome Open Research 2021, 6:153 Last updated: 02 JUL 2021
Corresponding author: Wala Kamchedzera (wala.kamchedzera@gmail.com) Author roles: Kamchedzera W: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Maheswaran H: Conceptualization, Methodology, Supervision, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Squire SB: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Joekes E: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Pai M: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Nliwasa M: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; G Lalloo D: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Webb EL: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Corbett EL: Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; MacPherson P: Conceptualization, Funding Acquisition, Methodology, Supervision, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests: No competing interests were disclosed. Grant information: PM was supported by the Wellcome Trust (grant number: WT206575). WK was supported by Wellcome (grant number: 218333/Z/19/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2021 Kamchedzera W et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original data is properly cited. How to cite this article: Kamchedzera W, Maheswaran H, Squire SB et al. Economic costs of accessing tuberculosis (TB) diagnostic services in Malawi: an analysis of patient costs from a randomised controlled trial of computer-aided chest x-ray interpretation [version 1; peer review: awaiting peer review] Wellcome Open Research 2021, 6:153 https://doi.org/10.12688/wellcomeopenres.16683.1 First published: 15 Jun 2021, 6:153 https://doi.org/10.12688/wellcomeopenres.16683.1
incurred catastrophic costs. Compared to SOC, there was no statistically significant difference in the mean total cost faced by those in the HIV (ratio: 0.77, 95% CI: 0.51, 1.19) and HIV/TB arms (ratio: 0.85, 95% CI: 0.53, 1.37). Conclusions: Despite the absence of user fees, patients seeking healthcare with TB symptoms incurred catastrophic costs. The optimised TB diagnostic interventions that were investigated in the PROSPECT study did not significantly reduce costs. TB diagnosis interventions should be implemented alongside social protection policies whilst ensuring healthcare facilities are accessible by the poor
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