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Evans, E. M., Nye, F., Beeching, Nicholas 
ORCID: https://orcid.org/0000-0002-7019-8791 and Gill, Geoff
(2005)
''Disappearing diabetes' - resolution of apparent Type 1 diabetes in a patient with AIDS and cytomegalovirus (CMV) infection'. Diabetic Medicine, Vol 22, Issue 2, pp. 218-220.
Abstract
A 30-year-old African female with established acquired immunodeficiency syndrome (AIDS) and no history of diabetes, presented in severe diabetic ketoacidosis (DKA). Blood pH was 6.96, serum bicarbonate 5 mmol/l, plasma glucose (PG) 33.0 mmol/l, and urine heavily positive for ketones. She responded to standard treatment and was established on twice-daily subcutaneous insulin. Four months later her insulin was stopped because of hypoglycaemic attacks on small doses. A glucose tolerance test (GTT) at 6 months postdiagnosis was normal (fasting PG 4.4 mmol/l and 2 h PG 7.5 mmol/l), and at 12 months random PG was 4.1 mmol/l and HbA(1c) 4.3%. The onset of her apparent Type 1 diabetes coincided with an HIV-associated cytomegalovirus (CMV) infection, and a reversible 'CMV insulitis' may be an explanation. Alternatively, the patient may have had what has recently been described as 'atypical diabetes' in African or Afro-Caribbean diabetic patients. Here resolution of diabetes may occur after presentation, though complete return to normoglycaemia after true DKA is very unusual.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hiv infection; aids; diabetes mellitus; type 1 diabetes diabetic ketoacidosis; cytomegalovirus; ketoacidosis; remission mellitus |
| Subjects: | WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WK Endocrine System > WK 810 Diabetes mellitus WK Endocrine System > WK 840 Diabetes as a complication in other conditions |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1111/j.1464-5491.2005.01364.x |
| Depositing User: | Ms Julia Martin |
| Date Deposited: | 01 Nov 2011 16:20 |
| Last Modified: | 14 Dec 2021 11:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1877 |
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