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An integrated genetic and physical map for the malaria vector Anopheles funestus

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Wondji, Charles ORCID: https://orcid.org/0000-0003-0791-3673, Hunt, R. H., Pignatelli, Patricia, Steen, Keith ORCID: https://orcid.org/0000-0002-8933-8643, Coetzee, M., Besansky, N., Lobo, N., Collins, F. H., Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 and Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 (2005) 'An integrated genetic and physical map for the malaria vector Anopheles funestus'. Genetics, Vol 171, Issue 4, pp. 1779-1787.

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Official URL: http://www.genetics.org/cgi/reprint/171/4/1779.pdf

Abstract

We have constructed a genetic map of the major African malaria vector, Anopheles funestus, using genetic markers segregating in F-2 progeny from crosses between two strains colonized from different field sites. Genotyping was performed on 174 progeny from three families using 33 microsatellite markers, a single RFLP, and 15 single nucleotide polymorphism (SNP) loci. Four linkage groups were resolved and these were anchored to chromosomes X and 2 and chromosomal arms 3R and 3L by comparison with a physical map of this species. Five markers were linked to the X chromosome, 16 markers to chromosome 2, and 10 and 11 markers to chromosomal arms 3R and 3L, respectively. This significantly increases the number of chromosomally defined genetic markers for this species and will facilitate the identification of genes controlling epidemiologically important traits such as resistance to insecticides or vector competence.

Item Type:	Article
Uncontrolled Keywords:	african microsatellite polymorphism mosquito gambiae resistance culicidae senegal diptera
Subjects:	QU Biochemistry > Genetics > QU 450 General Works QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WB Practice of Medicine > Medical Climatology > WB 700 Medical climatology. Geography of disease
Faculty: Department:	Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):	https://doi.org/10.1534/genetics.105.044800
Depositing User:	Ms Julia Martin
Date Deposited:	22 Jul 2011 11:12
Last Modified:	13 Sep 2019 15:47
URI:	https://archive.lstmed.ac.uk/id/eprint/1889

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