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Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes

Lissenden, Natalie ORCID: https://orcid.org/0000-0002-6578-5537, Kont, Mara, Essandoh, John, Ismail, Hanafy, Churcher, Thomas, Lambert, Ben, Lenhart, Audrey, McCall, Philip ORCID: https://orcid.org/0000-0002-0007-3985, Moyes, Catherine, Paine, Mark ORCID: https://orcid.org/0000-0003-2061-7713, Praulins, Giorgio, Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 and Lees, Rosemary ORCID: https://orcid.org/0000-0002-4232-9125 (2021) 'Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes'. Insects, Vol 12, Issue 9, p. 826.

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Abstract

Pyrethroid resistance is widespread in malaria vectors. However, differential mortality in discriminating dose assays to different pyrethroids is often observed in wild populations. When this occurs, it is unclear if this differential mortality should be interpreted as an indication of differential levels of susceptibility within the pyrethroid class, and if so, if countries should consider selecting one specific pyrethroid for programmatic use over another. A review of evidence from molecular studies, resistance testing with laboratory colonies and wild populations, and mosquito behavioural assays were conducted to answer these questions. Evidence suggested that in areas where pyrethroid resistance exists, different results in insecticide susceptibility assays with specific pyrethroids currently in common use (deltamethrin, permethrin, α-cypermethrin, and λ-cyhalothrin) are not necessarily indicative of an operationally relevant difference in potential performance. Consequently, it is not advisable to use rotation between these pyrethroids as an insecticide-resistance management strategy. Less commonly used pyrethroids (bifenthrin and etofenprox) may have sufficiently different modes of action, though further work is needed to examine how this may apply to insecticide resistance management.

Item Type: Article
Subjects: QX Parasitology > QX 4 General works
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.3390/insects12090826
Depositing User: Samantha Sheldrake
Date Deposited: 20 Sep 2021 12:25
Last Modified: 20 Sep 2021 12:28
URI: https://archive.lstmed.ac.uk/id/eprint/18946

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