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Li, Jing, Du, Yujiao, Liu, Yini, Du, Jiaoyang, Zhang, Ruo, Qu, Pengfei, Yan, Hong, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464 and Dang, Shaonong
(2021)
'Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population'. BMC Pregnancy and Childbirth, Vol 21, p. 677.
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12884_2021_Article_4154.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring. Methods: The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate the odds ratio and 95% confidence interval for the effects of life events on CHD. Results: After controlling for the potential confounders, the pregnant women experiencing the positive events during pregnancy had lower risk of CHD in offspring than those without positive events (OR = 0.38, 95%CI: 0.30 ~ 0.48). The risk of CHD in offspring could increase by 62% among the pregnant women experiencing the negative events compared to those without (OR = 1.62, 95%CI: 1.29 ~ 2.03). Both effects showed a certain dose-response association. Besides, the positive events could weaken the risk impact of negative events on CHD. Conclusion: It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare WG Cardiovascular System > WG 100 General works WG Cardiovascular System > Heart. Heart Diseases > WG 200 General works WS Pediatrics > Diseases of Children and Adolescents > By System > WS 290 Cardiovascular system |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1186/s12884-021-04154-0 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 08 Oct 2021 08:04 |
| Last Modified: | 08 Oct 2021 08:04 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/19119 |
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