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HIV-1 infection is associated with altered innate pulmonary immunity

Gordon, Stephen ORCID:, Janoff, E. N., Sloper, D., Zhang, Q. B., Read, R. C., Zijlstra, E. E., Finn, A. and Molyneux, Malcolm E (2005) 'HIV-1 infection is associated with altered innate pulmonary immunity'. Journal of Infectious Disease, Vol 192, Issue 8, pp. 1412-1416.

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We obtained bronchoalveolar lavage (BAL) fluid from 45 Ma-lawian adults, to measure the concentrations of innate pulmonary immune factors that are important in lung defense against infection. Increased concentrations of the beta-chemokine RANTES were found in BAL fluid from the human immunodeficiency virus (HIV)-1-infected subjects, compared with those in BAL fluid from the HIV-1-uninfected control subjects (mean, 86 pg/mL vs. 0 pg/mL;). Lysozyme concentrations were also elevated in the HIV-1-infected subjects, compared with those in the HIV-1-uninfected control subjects (1.9 mu g/mL vs. 1.1 mu g/mL;), but were not elevated in the HIV-1-infected subjects who had recently recovered from invasive pneumococcal disease. Concentrations of lactoferrin and secretory leukocyte protease inhibitor (SLPI) were not different when the subjects were compared by HIV- 1 serostatus. Concentrations of RANTES (R-2 = 0.68 and P <.0001) and SLPI (and) correlated with BAL fluid HIV-1 load but not with plasma HIV- 1 load.

Item Type: Article
Subjects: QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General)
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WF Respiratory System > WF 140 Diseases of the respiratory system (General)
Digital Object Identifer (DOI):
Depositing User: Ms Julia Martin
Date Deposited: 10 Aug 2011 15:44
Last Modified: 17 Aug 2022 08:56


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