Is continuous positive airway pressure therapy in COVID-19 associated with an increased rate of pulmonary barotrauma?

Jones, Lewis, Nightingale, Rebecca, Burhan, Hassan, Jones, Gareth, Barber, Kimberley, Bond, Helena, Parker, Robert, Duffy, Nick, Hampshire, Peter and Gautam, Manish (2021) 'Is continuous positive airway pressure therapy in COVID-19 associated with an increased rate of pulmonary barotrauma?'. ERJ Open Research, Vol 7, Issue 4.

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Abstract

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has infected over 150 million people worldwide, with over 3 million deaths as of 6 May 2021 [1]. In the UK, approximately 15% of individuals affected by coronavirus disease 2019 (COVID-19) have required admission to hospital [2] and those with severe disease require advanced respiratory support including invasive mechanical ventilation (IMV) [3]. Due to the considerable scale of the pandemic, noninvasive continuous positive airway pressure (CPAP) has been utilised for COVID-19-related type I respiratory failure as a therapeutic strategy to improve patient outcomes [4, 5] and also to preserve IMV capacity during a challenging time for acute healthcare providers. However, its exact role is unclear and is the subject of a UK multicentre trial [6].

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19 WF Respiratory System > WF 100 General works WF Respiratory System > Lungs > WF 600 Lungs
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1183/23120541.00886-2020
Depositing User:	Debbie Jenkins
Date Deposited:	04 Nov 2021 12:18
Last Modified:	03 Feb 2022 14:15
URI:	https://archive.lstmed.ac.uk/id/eprint/19315

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