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Simo Tchetgna, Huguette, Sado Yousseu, Francine, Kamgang, Basile, Tedjou, Armel, McCall, Philip 
ORCID: https://orcid.org/0000-0002-0007-3985 and Wondji, Charles ORCID: https://orcid.org/0000-0003-0791-3673
(2021)
'Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon'. PLoS Neglected Tropical Diseases, Vol 15, Issue 10, e0009860.
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Simo Tchetgna et al. 2021 Published version CW.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5’ and 3’ UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Infectious Mononucleosis. Arbovirus Infections > WC 528 Dengue WL Nervous System > WL 300 General works (Include works on brain alone) |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1371/journal.pntd.0009860 |
| Depositing User: | Mel Finley |
| Date Deposited: | 09 Nov 2021 13:03 |
| Last Modified: | 14 Mar 2022 12:49 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/19383 |
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