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Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon

Simo Tchetgna, Huguette, Sado Yousseu, Francine, Kamgang, Basile, Tedjou, Armel, McCall, Philip ORCID: and Wondji, Charles ORCID: (2021) 'Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon'. PLoS Neglected Tropical Diseases, Vol 15, Issue 10, e0009860.

Simo Tchetgna et al. 2021 Published version CW.pdf - Published Version
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Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5’ and 3’ UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > Infectious Mononucleosis. Arbovirus Infections > WC 528 Dengue
WL Nervous System > WL 300 General works (Include works on brain alone)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):
Depositing User: Mel Finley
Date Deposited: 09 Nov 2021 13:03
Last Modified: 14 Mar 2022 12:49


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