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Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study

Stockdale, Lisa, Sambou, Basil, Sissoko, Muhamed, Egere, Uzochukwu, Sillah, Abdou K., Kampmann, Beate and Basu Roy, Robin (2021) 'Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study'. European Journal of Pediatrics, Vol 181, Issue 3, pp. 1263-1267.

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Abstract

Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI − 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance.

Item Type: Article
Subjects: QU Biochemistry > Vitamins > QU 160 Vitamins. Vitamin requirements
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WS Pediatrics > WS 100 General works
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1007/s00431-021-04272-z
Depositing User: Rachel Dominguez
Date Deposited: 17 Nov 2021 11:04
Last Modified: 06 Apr 2022 14:04
URI: https://archive.lstmed.ac.uk/id/eprint/19449

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