Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium

Nzila, Alexis, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Marsh, Kevin, Sims, P. F. G. and Hyde, J. E. (2005) 'Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium'. Trends in Parasitology, Vol 21, Issue 7, pp. 334-339.

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Abstract

The follate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites. Whereas folate metabolism in mammalian cells and bacteria has been studied extensively, it is understood less well in malaria parasites. In two articles, we attempt to reconstitute the malaria folate pathway based on available information from mammalian and microbial systems, in addition to Plasmodium-genome-sequencing projects. In part 1, we focused on folate enzymes that are already used clinically as anticancer drug targets or that are under development in drug-discovery programs. In this article, we discuss mammalian folate enzymes that have not yet been exploited as potential drug targets, and enzymes that function in the de novo folate-synthesis pathway of the parasite - a particularly attractive area of attack because of its absence from the mammalian host.

Item Type:	Article
Uncontrolled Keywords:	antifolate drug synergy gtp cyclohydrolase-i dihydropteroate synthase dihydrofolate synthetase 10-formyltetrahydrofolate dehydrogenase formiminotransferase-cyclodeaminase bifunctional enzyme crystal-structure folic-acid falciparum
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.pt.2005.05.008
Depositing User:	Ms Julia Martin
Date Deposited:	16 Dec 2011 16:30
Last Modified:	06 Feb 2018 13:03
URI:	https://archive.lstmed.ac.uk/id/eprint/1974

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