Young, Neil D., Stroehlein, Andreas J., Wang, Tao, Korhonen, Pasi K., Mentink-Kane, Margaret, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420, Rollinson, David and Gasser, Robin B. (2022) 'Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium'. Nature Communications, Vol 13, Issue 1, p. 977.
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Abstract
Some snails act as intermediate hosts (vectors) for parasitic flatworms (flukes) that cause neglected tropical diseases, such as schistosomiases. Schistosoma haematobium is a blood fluke that causes urogenital schistosomiasis and induces bladder cancer and increased risk of HIV infection. Understanding the molecular biology of the snail and its relationship with the parasite could guide development of an intervention approach that interrupts transmission. Here, we define the genome for a key intermediate host of S. haematobium—called Bulinus truncatus—and explore protein groups inferred to play an integral role in the snail’s biology and its relationship with the schistosome parasite. Bu. truncatus shared many orthologous protein groups with Biomphalaria glabrata—the key snail vector for S. mansoni which causes hepatointestinal schistosomiasis in people. Conspicuous were expansions in signalling and membrane trafficking proteins, peptidases and their inhibitors as well as gene families linked to immune response regulation, such as a large repertoire of lectin-like molecules. This work provides a sound basis for further studies of snail-parasite interactions in the search for targets to block schistosomiasis transmission.
Item Type: | Article |
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Subjects: | QU Biochemistry > Genetics > QU 450 General Works QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QX Parasitology > Helminths. Annelida > QX 355 Schistosoma |
Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
Digital Object Identifer (DOI): | https://doi.org/10.1038/s41467-022-28634-9 |
SWORD Depositor: | JISC Pubrouter |
Depositing User: | JISC Pubrouter |
Date Deposited: | 22 Feb 2022 14:21 |
Last Modified: | 22 Feb 2022 14:21 |
URI: | https://archive.lstmed.ac.uk/id/eprint/20000 |
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