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Chronic obstructive pulmonary disease in sub-Saharan Africa

Awokola, Babatunde, Amusa, Gania .A, Jewell, C.P, Okello, Gabriel, Stolbrink, Marie, Finney, L.J, Mohammed, N, Erhart, A and Mortimer, Kevi ORCID: https://orcid.org/0000-0002-8118-8871 (2022) 'Chronic obstructive pulmonary disease in sub-Saharan Africa'. International Journal of Tuberculosis and Lung Disease, Vol 26, Issue 3, pp. 232-242.

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Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and an important cause of death in sub-Saharan Africa (SSA). We conducted a systematic review and meta-analysis on the prevalence of and risk factors for COPD in SSA.

METHODS: We conducted a protocol-driven systematic literature search in MEDLINE, EMBASE, CINAHL and Global Health, supplemented by a manual search of the abstracts from thoracic conference proceedings from 2017 to 2020. We did a meta-analysis of COPD prevalence and its association with current smoking.

RESULTS: We identified 831 titles, of which 27 were eligible for inclusion in the review and meta-analysis. The population prevalence of COPD ranged from 1.7% to 24.8% (pooled prevalence: 8%, 95% CI 6–11). An increased prevalence of COPD was associated with increasing age, smoking and biomass smoke exposure. The pooled odds ratio for the effect of current smoking (vs. never smoked) on COPD was 2.20 (95% CI 1.62–2.99).

CONCLUSION: COPD causes morbidity and mortality in adults in SSA. Smoking is an important risk factor for COPD in SSA, and this exposure needs to be reduced through the combined efforts of clinicians, researchers and policymakers to address this debilitating and preventable lung disease.

Item Type: Article
Subjects: WF Respiratory System > WF 140 Diseases of the respiratory system (General)
WF Respiratory System > WF 20 Research (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.5588/ijtld.21.0394
Depositing User: Debbie Jenkins
Date Deposited: 22 Mar 2022 12:35
Last Modified: 22 Mar 2022 12:35
URI: https://archive.lstmed.ac.uk/id/eprint/20044

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