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Infection history and current co-infection with Schistosoma mansoni decreases Plasmodium species intensities in pre-school children from Uganda

McDowell, Daniel, Hurt, Lisa, Kabatereine, Narcis B, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420 and Lello, Joanne (2022) 'Infection history and current co-infection with Schistosoma mansoni decreases Plasmodium species intensities in pre-school children from Uganda'. Journal of Infectious Disease. (In Press)

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Abstract

Malaria-schistosomiasis co-infections are common in sub-Saharan Africa but studies present equivocal results regarding the inter-specific relationships between these parasites. Through mixed model analyses of a dataset of Ugandan preschool children, we explore how current co-infection and prior infection with either Schistosoma mansoni or Plasmodium species, alter subsequent 1) Plasmodium intensity 2) Plasmodium risk and 3) S. mansoni risk. Co-infection and prior infections with S. mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
WS Pediatrics > By Age Groups > WS 440 Preschool child
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1093/infdis/jiac072
Depositing User: Marie Hatton
Date Deposited: 10 Mar 2022 14:34
Last Modified: 10 Mar 2022 14:34
URI: https://archive.lstmed.ac.uk/id/eprint/20053

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