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McDowell, Daniel, Hurt, Lisa, Kabatereine, Narcis B, Stothard, Russell 
ORCID: https://orcid.org/0000-0002-9370-3420 and Lello, Joanne
(2022)
'Infection history and current co-infection with Schistosoma mansoni decreases Plasmodium species intensities in pre-school children from Uganda'. Journal of Infectious Disease, Vol 225, Issue 12, pp. 2181-2186.
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jiac072_Accepted_2022.pdf - Accepted Version Available under License Creative Commons Attribution. Download (638kB) | Preview |
Abstract
Malaria-schistosomiasis co-infections are common in sub-Saharan Africa but studies present equivocal results regarding the inter-specific relationships between these parasites. Through mixed model analyses of a dataset of Ugandan preschool children, we explore how current co-infection and prior infection with either Schistosoma mansoni or Plasmodium species, alter subsequent 1) Plasmodium intensity 2) Plasmodium risk and 3) S. mansoni risk. Co-infection and prior infections with S. mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.
| Item Type: | Article |
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| Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis WS Pediatrics > By Age Groups > WS 440 Preschool child |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/infdis/jiac072 |
| Depositing User: | Marie Hatton |
| Date Deposited: | 10 Mar 2022 14:34 |
| Last Modified: | 29 Jun 2022 12:22 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/20053 |
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