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Lenhart, Audrey, Castillo, Carmen Elena, Villegas, Elci, Alexander, Neal, Vanlerberghe, Veerle, van der Stuyft, Patrick and McCall, Philip 
ORCID: https://orcid.org/0000-0002-0007-3985
(2022)
'Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela'. PLoS Neglected Tropical Diseases, Vol 16, Issue 3, e0010135.
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Lenhart et al PLOS NTDs 2022.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (2MB) | Preview |
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journal.pntd.0010135.pdf - Published Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview |
Abstract
Background
Following earlier trials indicating that their potential in dengue vector control was constrained by housing structure, a large-scale cluster-randomized trial of insecticide treated curtains (ITCs) and water jar covers (ITJCs) was undertaken in Venezuela.
Methods
In Trujillo, Venezuela, 60 clusters (6223 houses total) were randomized so that 15 clusters each received either PermaNet insecticide-treated window curtains (ITCs), permanent insecticide-treated water storage jar covers (ITJCs), a combination of both ITCs and ITJCs, or no insecticide treated materials (ITMs). A further 15 clusters located at least 5km from the edge of the study site were selected to act as an external control. Entomological surveys were carried out immediately before and after intervention, and then at 6-month intervals over the following 27 months. The Breteau and House indices were used as primary outcome measures and ovitrap indices as secondary. Negative binomial regression models were used to compare cluster-level values of these indices between the trial arms.
Results
Reductions in entomological indices followed deployment of all ITMs and throughout the trial, indices in the external control arm remained substantially higher than in the ITM study arms including the internal control. Comparing the ratios of between-arm means to summarise the entomological indices throughout the study, the combined ITC+ITJC intervention had the greatest impact on the indices, with a 63% difference in the pupae per person indices between the ITC+ITJC arm and the internal control. However, coverage had fallen below 60% by 14-months post-intervention and remained below 40% for most of the remaining study period.
Conclusions
ITMs can impact dengue vector populations in the long term, particularly when ITCs and ITJCs are deployed in combination.
| Item Type: | Article |
|---|---|
| Subjects: | QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Virus Diseases > Infectious Mononucleosis. Arbovirus Infections > WC 528 Dengue |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1371/journal.pntd.0010135 |
| Depositing User: | Samantha Sheldrake |
| Date Deposited: | 14 Mar 2022 12:22 |
| Last Modified: | 29 Jun 2022 11:22 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/20105 |
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