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Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

FitzGerald, Richard, Dickinson, Laura, Else, Laura, Fletcher, Tom, Hale, Colin, Amara, Alieu, Walker, Lauren, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria, Greenhalf, William, Bullock, Katie, Lavelle-Langham, Lara, Reynolds, Helen, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth and Khoo, Saye (2022) 'Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection'. Clinical Infectious Diseases. (In Press)

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Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

Item Type: Article
Subjects: QV Pharmacology > QV 38 Drug action.
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/cid/ciac199
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 07 Apr 2022 14:55
Last Modified: 29 Jun 2022 12:23
URI: https://archive.lstmed.ac.uk/id/eprint/20134

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