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Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis

Cheliotis, Katerina, Jewell, Christopher P., SolorzanoGonzalez, Carla, Urban, Britta ORCID: https://orcid.org/0000-0002-4197-8393, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Mitsi, Elena, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, Nikolaou, Elissavet, German, Esther, Reiné, Jesús, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Jochems, Simon ORCID: https://orcid.org/0000-0002-4835-1032, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611 and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2022) 'Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis'. ERJ Open Research, Vol 8, Issue 2, e00586.

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Abstract

Streptococcus pneumoniae (pneumococcus) is the most commonly identified bacterial cause of pneumonia and the leading infectious cause of death in children under 5 years of age worldwide. Pneumococcal disease follows a seasonal pattern with increased incidence during winter. Pneumonia burden is also associated with poor air quality. Nasopharyngeal carriage of the bacterium is a pre-requisite of invasive disease.We aimed to determine if susceptibility to nasopharyngeal pneumococcal carriage varied by season and which environmental factors might explain such variation. We also evaluated the influence of sex on susceptibility of carriage. We collated data from five studies in which human volunteers underwent intranasal pneumococcal challenge. Generalised linear mixed-effects models were used to identify factors associated with altered risk of carriage acquisition, specifically climate and air-quality data.During 2011–2017, 374 healthy adults were challenged with type 6B pneumococcus. Odds of carriage were significantly lower in males (OR, 0.61; 95% CI, 0.40–0.92; p=0.02), and higher with cooler temperatures (OR, 0.79; 95% CI, 0.63–0.99; p=0.04). Likelihood of carriage was also associated with lower concentrations of local fine particulate matter concentrations (PM2.5) and increased local rainfall.In contrast to epidemiological series, experimental challenge allowed us to test propensity to acquisition during controlled exposures; immunological explanations for sex and climatic differences should be sought.

Item Type: Article
Subjects: WA Public Health > WA 30 Socioeconomic factors in public health (General)
WA Public Health > Sanitation. Environmental Control > General Sanitation and Environmental Control > WA 670 General works
WA Public Health > Air pollution > WA 754 Pollution and pollutants (incl. tobacco pollution; passive smoking)
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1183/23120541.00586-2021
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 16 Aug 2022 13:36
Last Modified: 16 Aug 2022 13:36
URI: https://archive.lstmed.ac.uk/id/eprint/20292

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