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Sex determination systems as the interface between male-killing bacteria and their hosts.

Hornett, Emily, Kageyama, Daisuke and Hurst, Gregory D D (2022) 'Sex determination systems as the interface between male-killing bacteria and their hosts.'. Proceedings of the Royal Society B-Biological Sciences, Vol 289, Issue 1972, p. 20212781.

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Arthropods host a range of sex-ratio-distorting selfish elements, including diverse maternally inherited endosymbionts that solely kill infected males. Male-killing heritable microbes are common, reach high frequency, but until recently have been poorly understood in terms of the host-microbe interaction. Additionally, while male killing should generate strong selection for host resistance, evidence of this has been scant. The interface of the microbe with host sex determination is integral to the understanding of how death is sex limited and how hosts can evolve evasion of male killing. We first review current knowledge of the mechanisms diverse endosymbionts use to induce male-specific death. We then examine recent evidence that these agents do produce intense selection for host nuclear suppressor elements. We argue, from our understanding of male-killing mechanisms, that suppression will commonly involve evolution of the host sex determination pathways and that the host's response to male-killing microbes thus represents an unrecognized driver of the diversity of arthropod sex determination. Further work is required to identify the genes and mechanisms responsible for male-killing suppression, which will both determine the components of sex determination (or other) systems associated with suppressor evolution, and allow insight into the mechanism of male killing itself.

Item Type: Article
Subjects: QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
QX Parasitology > QX 20 Research (General)
QX Parasitology > QX 45 Host-parasite relations
QX Parasitology > Arthropods > QX 460 Arthropods
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 16 Aug 2022 15:26
Last Modified: 15 Jun 2023 13:21


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