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Yao, Jiashu, Li, Wei, Liu, Yu, Wu, Tongzhi, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464, Arezina, Radivoj, Sun, Zilin and Qiu, Shanhu
(2022)
'Investigation of the association between lens autofluorescence ratio and diabetes: a cross-sectional study.'. Photodiagnosis and Photodynamic Therapy, Vol 38, e102888.
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LFR and Diabetes-RevisionV3yao-clean.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (465kB) | Preview |
Abstract
Lens autofluorescence ratio (LFR) is a novel approach to detect advanced glycation end products in a time-saving and non-invasive manner. However, its associations with glycemia and diabetes remain unclear. We conducted this study to address this issue in Chinese adults. We enrolled a total of 4,705 participants aged 20-70 years in China between May 2020 and January 2021 in a cross-sectional study. LFR was determined by biomicroscopy (ClearPath DS-120). Diabetes was ascertained by oral glucose tolerance test, self-reported history, and/or antidiabetic medication use. Correlation and logistic regression analyses were performed. LFR was higher in participants with diabetes than those without (23.27 ± 6.51 vs. 19.45 ± 5.08, p < 0.001). LFR correlated with fasting plasma glucose and hemoglobin A1c in the overall and diabetes-stratified populations. The odds of diabetes was increased by 6% per one percent higher of LFR after multivariable-adjustment (odds ratio (OR) 1.06, 95% CI 1.04-1.08, p < 0.001). Participants in the highest quartile of LFR had higher odds of diabetes compared with those in the lowest quartile (OR 1.83, 95% CI 1.33-2.52, p < 0.001). Mediation analysis showed that, insulin resistance, as assessed by triglyceride-glucose index, may underline the relationship between high LFR and increased odds of diabetes. LFR, a non-invasive indirect measure of advanced glycation end products, appears to be associated with glycemia and the risk of developing diabetes in Chinese adults.
| Item Type: | Article |
|---|---|
| Subjects: | WK Endocrine System > WK 20 Research (General) WK Endocrine System > WK 810 Diabetes mellitus WK Endocrine System > WK 880 Hyperinsulinism. Hyperglycemia. Hypoglycemia WW Ophthalmology > Manifestations of Disease. Poor Vision > WW 475 Eye manifestations of general disease |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.pdpdt.2022.102888 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 22 Sep 2022 12:00 |
| Last Modified: | 27 Sep 2023 09:15 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/20411 |
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