Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data.

Walker, Martin, Freitas, Luzia T, Halder, Julia B, Brack, Matthew, Keiser, Jennifer, King, Charles H, Levecke, Bruno, Ai-Lian Lim, Yvonne, Pieri, Otavio, Sow, Doudou, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420, Webster, Joanne P, Zhou, Xiao-Nong, Terry, Robert F, Guérin, Philippe J and Basáñez, Maria-Gloria (2022) 'Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data.'. Wellcome Open Research, Vol 7, p. 5.

Preview

Text PMC9020536.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

The Infectious Diseases Data Observatory (IDDO, https://www.iddo.org) has launched a clinical data platform for the collation, curation, standardisation and reuse of individual participant data (IPD) on treatments for two of the most globally important neglected tropical diseases (NTDs), schistosomiasis (SCH) and soil-transmitted helminthiases (STHs). This initiative aims to harness the power of data-sharing by facilitating collaborative joint analyses of pooled datasets to generate robust evidence on the efficacy and safety of anthelminthic treatment regimens. A crucial component of this endeavour has been the development of a Research Agenda to promote engagement with the SCH and STH research and disease control communities by highlighting key questions that could be tackled using data shared through the IDDO platform. Here, we give a contextual overview of the priority research themes articulated in the Research Agenda-a 'living' document hosted on the IDDO website-and describe the three-stage consultation process behind its development. We also discuss the sustainability and future directions of the platform, emphasising throughout the power and promise of ethical and equitable sharing and reuse of clinical data to support the elimination of NTDs.

Item Type:	Article
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 253 Anthelmintics QX Parasitology > Helminths. Annelida > QX 200 Helminths WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 800 Helminthiasis WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.12688/wellcomeopenres.17468.1
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	05 Jul 2022 15:00
Last Modified:	16 Jun 2023 08:40
URI:	https://archive.lstmed.ac.uk/id/eprint/20530

Statistics

View details

Actions (login required)

Edit Item