Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.

Kontogianni, Konstantina, Bengey, Daisy, Wooding, Dominic, Buist, Kate, Greenland-Bews, Caitlin, Williams, Chris, Vos, Margaretha de, Santos, Victor Santana, Escadafal, Camille, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Edwards, Thomas and CubasAtienzar, Ana (2022) 'Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.'. Revista da Sociedade Brasileira de Medicina Tropical, Vol 55, e0016.

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Abstract

Background:

The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.

Methods:

Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant.

Results:

Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.

Conclusions:

This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 573 Antigens WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1590/0037-8682-0016-2022
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	22 Sep 2022 12:54
Last Modified:	16 Jun 2023 12:15
URI:	https://archive.lstmed.ac.uk/id/eprint/20632

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