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Inferring the epidemiological benefit of indoor vector control interventions against malaria from mosquito data

Sherrard-Smith, Ellie, Ngufor, Corine, Sanou, Antoine, Guelbeogo, Moussa W., N’Guessan, Raphael, Elobolobo, Eldo, Saute, Francisco, Varela, Kenyssony, Chaccour, Carlos J., Zulliger, Rose, Wagman, Joseph, Robertson, Molly L., Rowland, Mark, Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Gonahasa, Samuel, Staedke, Sarah G., Kolaczinski, Jan and Churcher, Thomas S. (2022) 'Inferring the epidemiological benefit of indoor vector control interventions against malaria from mosquito data'. Nature Communications, Vol 13, Issue 1, e3862.

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Abstract

The cause of malaria transmission has been known for over a century but it is still unclear whether entomological measures are sufficiently reliable to inform policy decisions in human health. Decision-making on the effectiveness of new insecticide-treated nets (ITNs) and the indoor residual spraying of insecticide (IRS) have been based on epidemiological data, typically collected in cluster-randomised control trials. The number of these trials that can be conducted is limited. Here we use a systematic review to highlight that efficacy estimates of the same intervention may vary substantially between trials. Analyses indicate that mosquito data collected in experimental hut trials can be used to parameterize mechanistic models for Plasmodium falciparum malaria and reliably predict the epidemiological efficacy of quick-acting, neuro-acting ITNs and IRS. Results suggest that for certain types of ITNs and IRS using this framework instead of clinical endpoints could support policy and expedite the widespread use of novel technologies.

Item Type: Article
Subjects: QX Parasitology > QX 20 Research (General)
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1038/s41467-022-30700-1
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 06 Oct 2022 11:10
Last Modified: 06 Oct 2022 11:10
URI: https://archive.lstmed.ac.uk/id/eprint/20722

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