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No evidence of lymphatic filariasis transmission in Bamako urban setting after three mass drug administration rounds

Coulibaly, Yaya Ibrahim, Sangare, Moussa, Dolo, Housseini, Soumaoro, Lamine, Coulibaly, Siaka Yamoussa, Dicko, Ilo, Diabaté, Abdoul Fatao, Diarra, Lamine, Coulibaly, Michel Emmanuel, Doumbia, Salif Seriba, Diallo, Abdallah Amadou, Dembele, Massitan, Koudou, Benjamin G., Bockarie, Moses John, Kelly-Hope, Louise ORCID:, Klion, Amy D. and Nutman, Thomas B. (2022) 'No evidence of lymphatic filariasis transmission in Bamako urban setting after three mass drug administration rounds'. Parasitology Research, Vol 121, Issue 11, pp. 3243-3248.

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Lymphatic filariasis (LF) elimination activities started in Mali in 2005 in the most endemic areas and reached countrywide coverage in 2009. In 2004, the district of Bamako was endemic for LF with a prevalence of 1.5%. The current study was designed to determine LF endemicity level in the urban area of Bamako after three rounds of ivermectin and albendazole mass drug administration (MDA). A cross-sectional study was conducted in 2011 in Bamako city, consisting of human prevalence and entomological surveys. Volunteers aged 14 years and above were invited to participate and tested for evidence of Wuchereria bancrofti using night time blood thick smear microfilarial count and blood spots for LF antibodies using the SD BIOLINE Oncho/LF IgG4 Biplex rapid test (Ov16/Wb123). Mosquitoes were collected using CDC light and gravid traps and tested using molecular methods. Poolscreen software v2.0 was used to estimate vector transmission potential. Of the 899 volunteers, one (0.11%) was found to be positive for LF using the Oncho/LF IgG4 Biplex rapid test, and none was found to have Wuchereria bancrofti microfilariae. No mosquitoes were found infected among 6174 Culex spp. (85.2%), 16 Anopheles gambiae s.l. (An. gambiae s.l.) (0.2%), 26 Aedes spp. (0.4%), 858 Ceratopogonidae (11.8%) and 170 other insects not identified (2.3%) tested. Our data indicate that there was no active LF transmission in the low prevalence urban district of Bamako after three MDA rounds. These data helped the National LF programme move forward towards the elimination goal.

Item Type: Article
Additional Information: 10 November 2022 A Correction to this paper has been published:
Subjects: WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine.
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
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SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 15 Dec 2022 10:39
Last Modified: 10 Mar 2023 10:02


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