Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae

Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Paton, M. G., Jensen, B., McCarroll, L., Vaughan, Ashley, Hogan, J. R., Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 and Collins, F. H. (2004) 'Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae'. Insect Molecular Biology, Vol 13, Issue 4, pp. 379-386.

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Abstract

Resistance to permethrin in an East African population of the major malaria vector, Anopheles gambiae is multifactorial. A mutated sodium channel allele and enhanced insecticide metabolism contribute to the resistance phenotype. We used microsatellite markers to scan the genome for quantitative trait loci (QTL) associated with permethrin resistance. Two major and one minor QTL were identified. The first QTL, rtp1, colocalizes with the sodium channel gene on chromosome 2L thus further supporting the importance of mutations in this gene in conferring permethrin resistance. The second two loci are located on the third chromosome and one of these, rtp2, flanks a large cluster of cytochrome P450 genes. Further detailed mapping of these regions will help elucidate the molecular mechanisms of metabolic resistance to insecticides.

Item Type:	Article
Uncontrolled Keywords:	quantitative trait loci microsatellites pyrethroid resistance cytochrome p450s kdr pyrethroid resistance insecticide resistance cytochrome-p450 genes ddt expression sequence mosquito strains loci
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance. QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):	https://doi.org/10.1111/j.0962-1075.2004.00495.x
Depositing User:	Sarah Lewis-Newton
Date Deposited:	16 Jan 2012 16:03
Last Modified:	17 Jul 2020 10:58
URI:	https://archive.lstmed.ac.uk/id/eprint/2163

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