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Childhood tuberculosis: clinical research needs

Graham, Stephen, Gie, R. P., Schaaf, H. S., Coulter, John B.S., Espinal, M. A. and Beyers, N. (2004) 'Childhood tuberculosis: clinical research needs'. International Journal of Tuberculosis and Lung Disease, Vol 8, Issue 5, pp. 648-657.

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Childhood tuberculosis (TB) is common in the developing world, where over 90% of global TB cases occur, and has increased in human immunodeficiency virus (HIV) endemic regions. Most children with TB are not infectious, and so, from a public health perspective, are not afforded the same priority by TB control programmes as older age groups in settings of limited resources. In addition, the diagnosis of pulmonary TB is particularly difficult in young children. This has resulted in TB being a neglected disease in children, although it causes substantial morbidity and mortality. This review summarises the current knowledge of clinical aspects of childhood TB management, and aims to identify priority areas for future research. The most critical need is for improved capability to confirm diagnosis. This would lead to better management of childhood TB and would greatly enhance our ability to conduct meaningful research in many related areas, including immunological studies which could lead to a more effective vaccine. Also important are a better understanding of risk factors for infection and disease, including the impact of HIV, and operational research to improve treatment outcomes and management of well childhood contacts.

Item Type: Article
Uncontrolled Keywords: tuberculosis child diagnosis treatment hiv human-immunodeficiency-virus positive pulmonary tuberculosis polymerase-chain-reaction hiv-endemic area mycobacterium-tuberculosis south-africa young-children pediatric tuberculosis 1-infected children household contacts
Subjects: WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis
WF Respiratory System > Tuberculosis > WF 415 Tuberculosis in childhood
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Depositing User: Ms Julia Martin
Date Deposited: 26 Mar 2012 15:28
Last Modified: 23 Nov 2018 14:58


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