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Qiu, Shanhu, Wang, Qianqian, Chen, Wenji, Xie, Bo, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464, Cai, Xue, Sun, Zilin and Wu, Tongzhi
(2023)
'Cumulative Muscle Strength and Risk of Cardiovascular Disease and All-cause mortality: A Prospective Cohort Study.'. Archives of Medical Research, Vol 54, Issue 3, pp. 261-269.
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2023-Cumulative Muscle Strength and Risk of Cardiovascular Disease and All-cause mortality.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (731kB) | Preview |
Abstract
The existing literature regarding the association between muscle strength and cardiovascular disease (CVD) and all-cause mortality relies mostly on a single measurement of muscle strength but has seldomly focused on the accumulated exposure. This study explored the association between cumulative muscle strength and risks of CVD and all-cause mortality in middle-aged and older adults. A total of 6,972 patients from the China Health and Retirement Longitudinal Study, who underwent 3 repeated measurements of muscle strength over 4 years and were followed-up for another 3 years for CVD and all-cause mortality outcomes participated in this study. Muscle strength was evaluated by grip strength and chair-rising time. Cumulative muscle strength was calculated as the area under the curve. Odds ratio (OR) and 95% confidence intervals (CIs) were analyzed. The odds of CVD and all-cause mortality decreased as cumulative grip strength increased or cumulative chair-rising time decreased. For each 1 standard deviation (SD) increment in cumulative grip strength, the multivariable-adjusted OR for CVD and all-cause mortality were 0.81 (95% CI 0.73-0.91) and 0.85 (95% CI 0.73-0.99), respectively. For each 1 SD decrease in cumulative chair-rising time, the corresponding OR were 0.81 (95% CI 0.75-0.88) and 0.87 (95% CI 0.77-0.98), respectively. However, neither the change-slope of grip strength nor that of chair-rising time was related to decreased OR of CVD or of all-cause mortality. Cumulative muscle strength was associated with a reduced risk of CVD and all-cause mortality in middle-aged and older Chinese adults.
| Item Type: | Article |
|---|---|
| Subjects: | WE Musculoskeletal System > WE 20 Research (General) WG Cardiovascular System > WG 120 Cardiovascular diseases WG Cardiovascular System > WG 20 Research (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.arcmed.2023.01.002 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 27 Feb 2023 14:08 |
| Last Modified: | 31 Jan 2024 04:12 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/21976 |
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