LSTM Home > LSTM Research > LSTM Online Archive

The spread of the Leu-Phe kdr mutation through Anopheles gambiae complex in Burkina Faso: genetic introgression and de novo phenomena

Diabate, A., Brengues, C., Baldet, T., Dabire, K. R., Hougard, J. M., Akogbeto, M., Kengne, P., Simard, F., Guillet, P., Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 and Chandre, F. (2004) 'The spread of the Leu-Phe kdr mutation through Anopheles gambiae complex in Burkina Faso: genetic introgression and de novo phenomena'. Tropical Medicine & International Health, Vol 9, Issue 12, pp. 1267-1273.

Full text not available from this repository.

Abstract

During extensive sampling in Burkina Faso and other African countries, the Leu-Phe mutation producing the kdr pyrethroid resistance phenotype was reported in both Anopheles gambiae ss and A. arabiensis. This mutation was widely distributed at high frequency in the molecular S form of A. gambiae while it has been observed at a very low frequency in both the molecular M form and A. arabiensis in Burkina Faso. While the mutation in the M form is inherited through an introgression from the S form, its occurrence is a new and independent mutation event in A. arabiensis. Three nucleotides in the upstream intron of the kdr mutation differentiated A. arabiensis from A. gambiae ss and these specific nucleotides were associated with kdr mutation in A. arabiensis. Ecological divergences which facilitated the spread of the kdr mutation within the complex of A. gambiae ss in West Africa, are discussed.

Item Type: Article
Uncontrolled Keywords: pyrethroids kdr mutation introgression anopheles gambiae ss anopheles arabiensis molecular forms burkina faso africa knockdown-resistance kdr sodium-channel gene pyrethroid insecticide resistance polymerase-chain-reaction malaria vector molecular characterization incipient speciation chromosomal forms tobacco budworm west-africa
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-3156.2004.01336.x
Depositing User: Ms Julia Martin
Date Deposited: 07 Sep 2011 13:23
Last Modified: 06 Feb 2018 13:03
URI: https://archive.lstmed.ac.uk/id/eprint/2248

Statistics

View details

Actions (login required)

Edit Item Edit Item