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Saderi, L., Cabibbe, A. M., Puci, M., Di Lorenzo, B., Centis, R., Pontali, E., van den Boom, M., Muhwa, Jeremiah, D´Ambrosio, L., Denholm, J. T., Ferrara, G., Silva, D. R., Solovic, I., Spanevello, A., Visca, D., Sotgiu, G. and Migliori, G. B. (2023) 'A systematic review of the costs of diagnosis for multidrug-resistant/extensively drug-resistant TB in different settings'. The International Journal of Tuberculosis and Lung Disease, Vol 27, Issue 5, pp. 348-356.
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Final Cost-Paper_for submission_30Nov_rev.pdf - Accepted Version Download (481kB) | Preview |
Abstract
BACKGROUND:
We performed an analysis of the cost and relative merits of different strategies for the diagnosis of multidrug-resistant/extensively drug-resistant TB (MDR/XDR-TB) in different settings.
METHODS:
We systematically reviewed the published evidence on cost/cost-effectiveness of rapid MDR/pre-XDR-TB and other methods for XDR-TB testing up to September 2022. PRISMA guidelines were followed. Collected data were analysed using Stata v17 software. Cost data were reported in USD ($) and summarised by mean, standard deviation, and range. Country income level was defined according to the World Bank country classification. Three simplified scenarios were also used to explore testing implications, based on low, intermediate and high TB incidence.
RESULTS:
Of 157 records, 25 studies were included with 24 reporting the cost of Xpert/RIF and two that evaluated the implementation of the MTBDRplus test. The total rapid test cost ranged from $12.41–$218, including $1.13–$74.60 for reagents/consumables and $0.40–$14.34 for equipment.
CONCLUSION:
The cost of MDR/XDR-TB diagnostics is lower in low resource settings. However, the cost-effective implementation of MDR/XDR-TB diagnostic algorithms requires careful consideration of local resources to avoid missed identification and the use of inappropriate regimen.
| Item Type: | Article |
|---|---|
| Subjects: | WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.5588/ijtld.22.0657 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 03 Aug 2023 13:22 |
| Last Modified: | 01 Nov 2023 04:12 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/22499 |
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