Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2

Collings, Kieran, Boisdon, Cedric, Sham, Tung-Ting, Skinley, Kevin, Oh, Hyun-Kyung, Prince, Tessa, Ahmed, Adham, Pennington, Shaun ORCID: https://orcid.org/0000-0002-7160-6275, Brownridge, Philip J., Edwards, Thomas, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Eyers, Claire E., Lamb, Amanda, Myers, Peter and Maher, Simon (2023) 'Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2'. Nature Communications, Vol 14, Issue 1, e5033.

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Abstract

The novel coronavirus pandemic (COVID-19) has necessitated a global increase in the use of face masks to limit the airborne spread of the virus. The global demand for personal protective equipment has at times led to shortages of face masks for the public, therefore makeshift masks have become commonplace. The severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2) has a spherical particle size of ~97 nm. However, the airborne transmission of this virus requires the expulsion of droplets, typically ~0.6–500 µm in diameter (by coughing, sneezing, breathing, and talking). In this paper, we propose a face covering that has been designed to effectively capture SARS-CoV-2 whilst providing uncompromised comfort and breathability for the wearer. Herein, we describe a material approach that uses amorphous silica microspheres attached to cotton fibres to capture bioaerosols, including SARS CoV-2. This has been demonstrated for the capture of aerosolised proteins (cytochrome c, myoglobin, ubiquitin, bovine serum albumin) and aerosolised inactivated SARS CoV-2, showing average filtration efficiencies of ~93% with minimal impact on breathability.

Item Type:	Article
Subjects:	WC Communicable Diseases > Virus Diseases > General Virus Diseases > WC 500 Virus diseases (General or not elsewhere classified) WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41467-023-40696-x
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	21 Aug 2023 10:48
Last Modified:	14 Sep 2023 12:23
URI:	https://archive.lstmed.ac.uk/id/eprint/22987

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