Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae

Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Nikou, Dimitra, Hutchinson, M., Wang, X., Roth, C. W., Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 and Collins, F. H. (2002) 'Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae'. Insect Molecular Biology, Vol 11, Issue 5, pp. 409-418.

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Abstract

Cytochrome P450s are a superfamily of haemoproteins, important in the metabolism of endogenous compounds and xenobiotics. As a first step to elucidating the role of this family in insecticide resistance in the malaria mosquito, Anopheles gambiae , we have cloned and mapped multiple P450 genes. Sixteen cDNAs encoding full-length P450s were cloned and physically mapped to the mosquito's polytene chromosomes. Fourteen of these encode putative CYP6 proteins and two encode P450s belonging to the CYP9 class. Eighteen new A. gambiae Cyp4 P450 genes were identified using degenerate PCR primers, cDNAs were detected for ten and in situ locations for thirteen members of this gene family.

Item Type:	Article
Uncontrolled Keywords:	mosquito;monooxygenases;insecticide resistance;polytene chromosomes;gene clusters
Subjects:	QU Biochemistry > Genetics > QU 450 General Works QU Biochemistry > Genetics > QU 470 Genetic structures QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Digital Object Identifer (DOI):	https://doi.org/10.1046/j.1365-2583.2002.00350.x
Depositing User:	Ms Julia Martin
Date Deposited:	25 Oct 2011 10:34
Last Modified:	22 Nov 2024 10:55
URI:	https://archive.lstmed.ac.uk/id/eprint/2318

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