Potassium status and the risk of type 2 diabetes, cardiovascular diseases, and mortality: a meta-analysis of prospective observational studies

Fan, Yahui, Wu, Min, Ding, Lu, Ji, Huixin, Zhao, Jinping, Li, Xiaohui, Li, Zhaofang, Liu, Sijiao, Jiang, Hong, Shi, Jia, Lei, Haoyuan, Wang, Mingxu, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464 and Ma, Le (2023) 'Potassium status and the risk of type 2 diabetes, cardiovascular diseases, and mortality: a meta-analysis of prospective observational studies'. Critical Reviews in Food Science and Nutrition, pp. 1-13. (In Press)

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Abstract

Epidemiological evidence on the association between potassium and cardiometabolic outcomes remains controversial. This study aimed to examine associations of dietary intake and blood and urinary levels of potassium with risk of type 2 diabetes, cardiovascular disease (CVD), and mortality. Relevant prospective studies were retrieved through a comprehensive search of four electronic databases up to July 1, 2023. Random-effects models were used to pool the study-specific relative risks (RRs) and 95% confidence intervals (CIs). Fifty-six studies were included in this meta-analysis. A higher intake of potassium was significantly associated with a 16% lower risk of CVD (RR: 0.84, 95% CI: 0.78–0.90). Similar inverse associations were also observed between potassium intake and mortality. Each 1.0 g/d increment in potassium intake was associated with a decreased risk of CVD (RR: 0.85, 95% CI: 0.80–0.91) and all-cause mortality (RR: 0.93, 95% CI: 0.88–0.99). For blood and urinary potassium levels, higher level of blood potassium increased the risk of all-cause mortality by 23% (RR: 1.23, 95% CI: 1.11–1.36). The association of blood potassium levels with mortality was nonlinear (Pnon-linearit<0.001). However, urinary potassium levels were inversely associated with the risk of all-cause mortality (RR: 0.84, 95% CI: 0.76–0.93). Our findings support the benefits of moderate potassium consumption for primary prevention of chronic diseases and premature death.

Item Type:	Article
Subjects:	QU Biochemistry > Vitamins > QU 145 Nutrition. Nutritional requirements WG Cardiovascular System > WG 120 Cardiovascular diseases WK Endocrine System > WK 810 Diabetes mellitus
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1080/10408398.2023.2262584
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	12 Oct 2023 09:54
Last Modified:	16 Feb 2024 14:36
URI:	https://archive.lstmed.ac.uk/id/eprint/23311

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