The effect and control of malaria in pregnancy and lactating women in the Asia-Pacific region

Unger, Holger W, Acharya, Sanjaya, Arnold, Lachlan, Wu, Connie, vanEijk, Anna ORCID: https://orcid.org/0000-0003-1635-1289, Gore-Langton, Georgia R, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617, Lufele, Elvin, Chico, R Matthew, Price, Ric N, Moore, Brioni R, Thriemer, Kamala and Rogerson, Stephen J (2023) 'The effect and control of malaria in pregnancy and lactating women in the Asia-Pacific region'. Lancet Global Health, Vol 11, Issue 11, e1805-e1818.

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Abstract

Half of all pregnancies at risk of malaria worldwide occur in the Asia-Pacific region, where Plasmodium falciparum and Plasmodium vivax co-exist. Despite substantial reductions in transmission, malaria remains an important cause of adverse health outcomes for mothers and offspring, including pre-eclampsia. Malaria transmission is heterogeneous, and infections are commonly subpatent and asymptomatic. High-grade antimalarial resistance poses a formidable challenge to malaria control in pregnancy in the region. Intermittent preventive treatment in pregnancy reduces infection risk in meso-endemic New Guinea, whereas screen-and-treat strategies will require more sensitive point-of-care tests to control malaria in pregnancy. In the first trimester, artemether-lumefantrine is approved, and safety data are accumulating for other artemisinin-based combinations. Safety of novel antimalarials to treat artemisinin-resistant P falciparum during pregnancy, and of 8-aminoquinolines during lactation, needs to be established. A more systematic approach to the prevention of malaria in pregnancy in the Asia-Pacific is required.

Item Type:	Article
Subjects:	WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WQ Obstetrics > Pregnancy > WQ 200 General works WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 125 Breast feeding
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/S2214-109X(23)00415-1
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	02 Nov 2023 13:21
Last Modified:	02 Nov 2023 13:21
URI:	https://archive.lstmed.ac.uk/id/eprint/23407

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