LSTM Home > LSTM Research > LSTM Online Archive

Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

Molina-Moya, Bárbara, Villar-Hernández, Raquel, Ciobanu, Nelly, Muriel-Moreno, Beatriz, Lacoma, Alicia, Codreanu, Alexandru, Latorre, Irene, Smalchuk, Daria, Prat-Aymerich, Cristina, Crudu, Valeriu, Kontogianni, Konstantina, Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 and Domínguez, José (2023) 'Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis'. Frontiers in Tuberculosis, Vol 1, p. 1267221.

[img]
Preview
Text
Table_2.pdf - Supplemental Material
Available under License Creative Commons Attribution.

Download (566kB) | Preview
[img]
Preview
Text
ftubr-01-1267221.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview
[img]
Preview
Text
Table_1.pdf - Supplemental Material
Available under License Creative Commons Attribution.

Download (563kB) | Preview

Abstract

Background: Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease.
Methods: CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study.
Results: In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (p < 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's r < 0.6) were found between biomarkers.
Conclusion: The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.

Item Type: Article
Subjects: WF Respiratory System > WF 20 Research (General)
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.3389/ftubr.2023.1267221
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 03 Jan 2024 12:14
Last Modified: 03 Jan 2024 12:14
URI: https://archive.lstmed.ac.uk/id/eprint/23680

Statistics

View details

Actions (login required)

Edit Item Edit Item