Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization

Abu-Raya, Bahaa, Esser, Mirjam J., Nakabembe, Eve, Reiné, Jesús, Amaral, Kyle, Diks, Annieck M., Imede, Esther, Way, Sing Sing, Harandi, Ali M., Gorringe, Andrew, Le Doare, Kirsty, Halperin, Scott A., Berkowska, Magdalena A. and Sadarangani, Manish (2023) 'Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization'. Journal of Molecular Biology, Vol 435, Issue 24, p. 168344.

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Abstract

Neither immunization nor recovery from natural infection provides life-long protection against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an acellular pertussis (aP) vaccine, mutations in B. pertussis strains, and better diagnostic techniques, contribute to resurgence of number of cases especially in young infants. Development of new immunization strategies relies on a comprehensive understanding of immune system responses to infection and immunization and how triggering these immune components would ensure protective immunity. In this review, we assess how B cells, and their secretory products, antibodies, respond to B. pertussis infection, current and novel vaccines and highlight similarities and differences in these responses. We first focus on antibody-mediated immunity. We discuss antibody (sub)classes, elaborate on antibody avidity, ability to neutralize pertussis toxin, and summarize different effector functions, i.e. ability to activate complement, promote phagocytosis and activate NK cells. We then discuss challenges and opportunities in studying B-cell immunity. We highlight shared and unique aspects of B-cell and plasma cell responses to infection and immunization, and discuss how responses to novel immunization strategies better resemble those triggered by a natural infection (i.e., by triggering responses in mucosa and production of IgA). With this comprehensive review, we aim to shed some new light on the role of B cells and antibodies in the pertussis immunity to guide new vaccine development.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jmb.2023.168344
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	02 Jan 2024 09:57
Last Modified:	02 Jan 2024 09:57
URI:	https://archive.lstmed.ac.uk/id/eprint/23710

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