Typhoid fever.

Meiring, James E, Khanam, Farhana, Basnyat, Buddha, Charles, Richelle C, Crump, John A, Debellut, Frederic, Holt, Kathryn E, Kariuki, Samuel, Mugisha, Emmanuel, Neuzil, Kathleen M, Parry, Christopher, Pitzer, Virginia E, Pollard, Andrew J, Qadri, Firdausi and Gordon, Melita A (2023) 'Typhoid fever.'. Nature Reviews Disease primers, Vol 9, Issue 1, e71.

Text TyphoidFever_NaturePrimer_REF.pdf - Accepted Version Restricted to Repository staff only until 14 June 2024. Download (921kB)

Abstract

Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa and Asia. Typhoid primarily affects individuals ranging from infants through to young adults. The causative organism, Salmonella enterica subsp. enterica serovar Typhi is transmitted via the faecal-oral route, crossing the intestinal epithelium and disseminating to systemic and intracellular sites, causing an undifferentiated febrile illness. Blood culture remains the practical reference standard for diagnosis of typhoid fever, where culture testing is available, but novel diagnostic modalities are an important priority under investigation. Since 2017, remarkable progress has been made in defining the global burden of both typhoid fever and antimicrobial resistance; in understanding disease pathogenesis and immunological protection through the use of controlled human infection; and in advancing effective vaccination programmes through strategic multipartner collaboration and targeted clinical trials in multiple high-incidence priority settings. This Primer thus offers a timely update of progress and perspective on future priorities for the global scientific community.

Item Type:	Article
Subjects:	WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 270 Typhoid fever
Faculty: Department:	Education
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41572-023-00480-z
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	05 Mar 2024 14:29
Last Modified:	05 Mar 2024 14:29
URI:	https://archive.lstmed.ac.uk/id/eprint/23754

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