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Hill, Jenny 
ORCID: https://orcid.org/0000-0003-1588-485X, Accrombessi, Manfred, Briand, Valérie, Dhabangi, Aggrey, Hoyt, Jenna, Idro, Richard, Khairallah, Carole, Kariuki, Simon, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617, Kwambai, Titus, Luty, Adrian J. F., Manda-Taylor, Lucinda, Massougbodji, Achille, Otieno, Juliet, Phiri, Kamija S., Rosu, Laura, Rujumba, Joseph, Seddon, Tracy, Tangara, Brian, Vincent, Jeanne Perpétue and Worrall, Eve ORCID: https://orcid.org/0000-0001-9147-3388
(2024)
'Implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda: stakeholder engagement meeting report'. Malaria Journal, Vol 23, Issue 1, e89.
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PDMC Saves Lives Stakeholder meeting report_MJ 2024.pdf - Published Version Available under License Creative Commons Attribution. Download (969kB) | Preview |
Abstract
A Stakeholder engagement meeting on the implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda was held in Nairobi, Kenya, on 27 September 2023. Representatives from the respective National Malaria Control Programmes, the World Health Organization (WHO) Geneva, Africa
Regional and Kenya offices, research partners, non-governmental rganizations, and the Medicines for Malaria Venture participated. PDMC was recommended by the WHO in June 2022 and involves provision of a full anti-malarial treatment course at regular intervals during the post-discharge period in children hospitalized with severe anaemia in areas of moderate-to-high malaria transmission. The WHO recommendation followed evidence from a meta-analysis of three clinical trials and from acceptability, delivery, cost-ffectiveness, and modelling studies. The trials were conducted in The Gambia using monthly sulfadoxine-pyrimethamine during the transmission season, in Malawi using monthly artemether-lumefantrine, and in Kenya and Uganda using monthly dihydroartemisinin-piperaquine, showing a significant reduction in all-cause mortality by 77% (95% CI 30–98) and a 55% (95% CI 44–64) reduction in all-cause hospital readmissions 6 months post-discharge. The recommendation has not yet been implemented in sub-Saharan Africa. There is no established platform for PDMC delivery. The objectives of the meeting were for the participating countries to share country contexts, plans and experiences regarding the adoption and implementation of PDMC
and to explore potential delivery platforms in each setting. The meeting served as the beginning of stakeholder engagement within the PDMC Saves Lives project and will be followed by formative and implementation research to evaluate alternative delivery strategies in selected countries. Meeting highlights included country consensus
on use of dihydroartemisinin-piperaquine for PDMC and expansion of the target group to "severe anaemia or severe malaria", in addition to identifying country-specific options for PDMC delivery for evaluation in implementation research. Further exploration is needed on whether the age group should be extended to school-age children.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine. WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Health Administration and Organization > WA 540 National and state health administration WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1186/s12936-023-04810-0 |
| Depositing User: | Tracy Seddon |
| Date Deposited: | 02 Apr 2024 13:38 |
| Last Modified: | 02 Apr 2024 13:38 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/24288 |
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