Experimental human pneumococcal carriage models for vaccine research

Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902, Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210 and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2011) 'Experimental human pneumococcal carriage models for vaccine research'. Trends in Microbiology, Vol 19, Issue 9, pp. 464-470.

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Abstract

Pneumococcal conjugate vaccines have had unprecedented success in controlling vaccine-type invasive pneumococcal disease. As serotype replacement and the complexity of designing vaccines to multiple capsular polysaccharides ultimately pose a threat to these vaccines, the development of alternative protein vaccines is important. Protein vaccines offer the promise of extended serotype coverage, reduced cost, and improved protection against otitis media and pneumococcal pneumonia. As placebo-controlled trials are not currently ethically justifiable, human pneumococcal challenge models using prevention of carriage as a test endpoint offer an attractive link between preclinical studies and clinical efficacy trials. Experimental human pneumococcal carriage studies offer a means of describing mechanisms of protection against carriage and a clinical tool to choose between vaccine candidates

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Bacteria > QW 142 Gram-positive bacteria (General) QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.tim.2011.06.003
Depositing User:	Users 43 not found.
Date Deposited:	23 Nov 2011 15:26
Last Modified:	05 Nov 2019 14:56
URI:	https://archive.lstmed.ac.uk/id/eprint/2438

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