Impact of four years of annually repeated indoor residual spraying (IRS) with Actellic 300CS on routinely reported malaria cases in an agricultural setting in Malawi

HoekSpaans, Remy, Mkumbwa, Albert, Nasoni, Peter, Jones, Christopher M. and Stanton, Michelle C. (2024) 'Impact of four years of annually repeated indoor residual spraying (IRS) with Actellic 300CS on routinely reported malaria cases in an agricultural setting in Malawi'. PLOS Global Public Health, Vol 4, Issue 4, e0002264.

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Abstract

Indoor residual spraying (IRS) is one of the main vector control tools used in malaria prevention. This study evaluates IRS in the context of a privately run campaign conducted across a low-lying, irrigated, sugarcane estate from Illovo Sugar, in the Chikwawa district of Malawi. The effect of Actellic 300CS annual spraying over four years (2015-2018) was assessed using a negative binomial mixed effects model, in an area where pyrethroid resistance has previously been identified. With an unadjusted incidence rate ratio (IRR) of 0.38 (95% CI: 0.32–0.45) and an adjusted IRR of 0.50 (95% CI: 0.42-0.59), IRS has significantly contributed to a reduction in case incidence rates at Illovo, as compared to control clinics and time points outside of the six month protective period. This study shows how the consistency of a privately run IRS campaign can improve the health of employees. More research is needed on the duration of protection and optimal timing of IRS programmes.

Item Type:	Article
Subjects:	WA Public Health > WA 20.5 Research (General) WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Repository link:	Item title Item URI Dataset and code to reproduce analysis on the impact of indoor residual spraying (IRS) on malaria at Illovo Nchalo, Malawi https://archive.lstmed.ac.uk/id/eprint/24520
Faculty: Department:	Education
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pgph.0002264
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	07 May 2024 13:17
Last Modified:	07 May 2024 13:24
URI:	https://archive.lstmed.ac.uk/id/eprint/24449

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