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Nsomba, Edna, Chirwa, Anthony E., Ngoliwa, Clara, Nkhoma, Vitumbiko, Liwonde, Pemphero, Mangani, Edward, Reuben, Modesta, Chimgoneko, Lorensio, Makhaza, Lumbani, Kudowa, Evaristar, Henrion, Marc, Toto, Neema, Gordon, Stephen 
ORCID: https://orcid.org/0000-0001-6576-1116 and Dula, Dingase
(2024)
'Recruitment strategies used to enrol healthy volunteers in the first pneumococcal human infection study in Africa: Lessons from Blantyre, Malawi'. Wellcome Open Research, Vol 9, e216.
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Recruitment strategies used to enrol healthy volunteers in the first pneumococcal human infection study in Africa- Lessons from Blantyre Malawi.pdf - Published Version Available under License Creative Commons Attribution. Download (636kB) | Preview |
Abstract
Background
Human infection studies (HIS) also known as Controlled Human Infection Models (CHIM) are a relatively new concept in African countries to clinicians, scientists, and communities alike. We have introduced HIS/CHIM studies to Malawi during the last four years by developing an experimental human pneumococcal carriage model. This CHIM was used to test the efficacy of a licensed 13-valent Pneumococcal Conjugate Vaccine (PCV13) against experimental nasal pneumococcal carriage. Traditional and digital recruitment strategies into this novel trial were explored.
Objectives
To describe various methods of recruitment in this first CHIM study in Malawi.
Methods
The clinical trial within the context of which these data were recorded was registered with the Pan African Clinical Trials Registry (REF: PACTR202008503507113) on 03 August 2020. The project was conducted at the Malawi Liverpool Wellcome Programme (MLW) in Blantyre, Malawi between April 2021, and September 2022. Source populations were college students and community members within Blantyre. Recruitment strategies included sharing study information in written or visual form, community sensitization meetings, snowball contacts (word of mouth from previous volunteers), branded clothing and participating in radio and television programs.
Results
299 volunteers attended screening clinic, of whom 278 were recruited. Sixty-six recruited volunteers (23.7%) were college students and 212 (76.3%) were from the community. Snowball word-of-mouth contacting was the most successful recruitment strategy, with 201 (72.3%) participants recruited using this method. 195 (70.1%) were men of whom 149 (76.4%) joined the study through snowballing.
Conclusion or recommendation
Using a variety of recruitment strategies led to successful recruitment in this novel controlled human infection study. Most participants were recruited through snowballing.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > WA 20.5 Research (General) WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.12688/wellcomeopenres.19271.1 |
| Depositing User: | Leah Dempsey |
| Date Deposited: | 14 May 2024 14:05 |
| Last Modified: | 14 May 2024 14:05 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/24552 |
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