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European Vaccine Initiative: lessons from developing malaria vaccines.

Geels, Mark J., Imoukhuede, Egeruan B., Imbault, Nathalie, van Schooten, Harry, McWade, Terry, Troye-Blomberg, Marita, Dobbelaer, Roland, Craig, Alister ORCID: and Leroy, Odile (2011) 'European Vaccine Initiative: lessons from developing malaria vaccines.'. Expert review of vaccines, Vol 10, Issue 12, pp. 1697-1708.

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For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trials, two of which have been transitioned for further clinical development in sub-Saharan Africa. Since its inception the EVI organization has operated as a funding agency, but with a clear service-oriented strategy. The scientific successes and difficulties encountered during these years and how these efforts have led to standardization and harmonization in vaccine development through large-scale European consortia are discussed. In the future, the EVI will remain instrumental in the pharmaceutical and clinical development of vaccines against ?diseases of poverty? with a continued focus on malaria. EVI will continue to focus on funding and managing preclinical evaluation up to Phase I/II clinical trials and strengthening the vaccine-development infrastructure in Europe, albeit with a global orientation.

Item Type: Article
Additional Information: The original version is the electronic one and can be found at:
Uncontrolled Keywords: diseases of poverty; EMVI; EVI; malaria; PDP; research infrastructure; vaccine
Subjects: QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Digital Object Identifer (DOI):
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Depositing User: Mary Creegan
Date Deposited: 07 Dec 2011 11:04
Last Modified: 25 Jan 2022 09:56


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